Completed studies
Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease (MAC2v3)
- Primary Investigator: Kevin Winthrop, MD, MPH
- Funder: Patient-Centered Outcomes Research Institute (PCORI)
- Project Summary: This multicenter, randomized, pragmatic clinical trial is designed to compare azithromycin + ethambutol (2-drug therapy) with azithromycin + ethambutol + rifampin (3-drug therapy) and to determine whether the 2-drug regimen is non-inferior for non-cavitary pulmonary MAC disease. The primary outcome is culture conversion.
- Clinicaltrials.gov link: https://clinicaltrials.gov/study/NCT03672630
Clofazimine in the Treatment of Pulmonary Mycobacterium Avium Complex (MAC)
- Primary Investigator: Kevin Winthrop, MD, MPH
- Funder: U.S. Food & Drug Administration (FDA)
- Project Summary: The purpose of this study is to evaluate the clinical effectiveness and safety of clofazimine when used to treat Mycobacteria avium complex (MAC) lung disease.
- Clinicaltrials.gov link: https://clinicaltrials.gov/study/NCT02968212
Development of Pulmonary Nontuberculous Mycobacterial Disease Symptom Scale (NTM-SS), Pulmonary NTM Infection
- Primary Investigator: Emily Henkle, PhD
- Funder: U.S. Food & Drug Administration (FDA)
- Project Summary: The objective of this study was to develop, test, and validate a disease-specific patient-reported outcome (PRO) measure in well-characterized population of patients with NTM.
- Trial Link: https://link.springer.com/article/10.1007/s11136-026-04227-7
